brown adipose tissue in morbidly obese subjects褐色脂肪组织在病态肥胖受试者.pdf

Brown Adipose Tissue in Morbidly Obese Subjects 1,2 2 3 3 1 Guy H. E. J. Vijgen , Nicole D. Bouvy , G. J. Jaap Teule , Boudewijn Brans , Patrick Schrauwen , Wouter D. van Marken Lichtenbelt1* 1 Department of Human Biology, School for Nutrition and Toxicology and Metabolism - NUTRIM, Maastricht University, Maastricht, The Netherlands, 2 Department of General Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands, 3 Department of Nuclear Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands Abstract Background: Cold-stimulated adaptive thermogenesis in brown adipose tissue (BAT) to increase energy expenditure is suggested as a possible therapeutic target for the treatment of obesity. We have recently shown high prevalence of BAT in adult humans, which was inversely related to body mass index (BMI) and body fat percentage (BF%), suggesting that obesity is associated with lower BAT activity. Here, we examined BAT activity in morbidly obese subjects and its role in cold- induced thermogenesis (CIT) after applying a personalized cooling protocol. We hypothesize that morbidly obese subjects show reduced BAT activity upon cold exposure. Methods and Findings: After applying a personalized cooling protocol for maximal non-shivering conditions, BAT activity was determined using positron-emission tomography and computed tomography (PET-CT). Cold-induced BAT activity was detected in three out of 15 morbidly obese subjects. Combined with results from lean to morbidly obese subjects (n = 39) from previous study, the collective data show a highly significant correlation between BAT activity and body composition (P,0.001), respectively explaining 64% and 60% of the variance in B