brown adipose tissue in humans is activated by elevated plasma catecholamines levels and is inversely related to central obesity褐色脂肪组织在人类激活血浆儿茶酚胺水平升高和逆相关中央肥胖.pdf

Brown Adipose Tissue in Humans Is Activated by Elevated Plasma Catecholamines Levels and Is Inversely Related to Central Obesity 1,2. 3. 1,2 1,2 1,2 1,2 3 Qidi Wang , Min Zhang , Guang Ning , Weiqiong Gu , Tingwei Su , Min Xu , Biao Li , Weiqing Wang1,2* 1 Shanghai Key Laboratory for Endocrine Tumors and Key Laboratory for Endocrine and Metabolic Diseases of Chinese Health Ministry, Rui-Jin Hospital, Shanghai Jiao- Tong University School of Medicine, Shanghai, China, 2 Shanghai Clinical Center for Endocrine and Metabolic Diseases and Division of Endocrinology and Metabolism of The E-Institute of Shanghai Universities, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China, 3 Department of Nuclear Medicine, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China Abstract Background: Recent studies have shown that adult human possess active brown adipose tissue (BAT), which might be important in controlling obesity. It is known that ß-adrenoceptor-UCP1 system regulates BAT in rodent, but its influence in adult humans remains to be shown. The present study is to determine whether BAT activity can be independently stimulated by elevated catecholamines levels in adult human, and whether it is associated with their adiposity. Methodology/Principal Findings: We studied 14 patients with pheochromocytoma and 14 normal subjects who had performed both 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) and plasma total metanephrine (TMN) measurements during 2007–2010. The BAT detection rate and the mean BAT activity were significantly higher i