de novo lipogenesis in adipose tissue is associated with course of morbid obesity after bariatric surgery脂肪从头合成脂肪组织与课程相关的减肥手术后病态肥胖.pdf

De Novo Lipogenesis in Adipose Tissue Is Associated with Course of Morbid Obesity after Bariatric Surgery ´ 1 1 ´ ´ 2,3 ´ 2 Lourdes Garrido-Sanchez , Joan Vendrell , Diego Fernandez-Garcıa , Victoria Ceperuelo-Mallafre , ´ 1 ˜ 4 5 2,3 ´ Matilde R. Chacon , Luis Ocana-Wilhelmi , Juan Alcaide , Francisco J. Tinahones *, Eduardo Garcıa- Fuentes3,5* ´ ´ ´ ´ 1 CIBERDEM, Hospital Universitari Joan XXIII, IISPV, Tarragona, Spain, 2 Servicio de Endocrinologıa y Nutricion, Hospital Clınico Virgen de la Victoria, Malaga, Spain, 3 Ciber ´ ´ ´ ´ ´ ´ ´ ´ Fisiopatologıa Obesidad y Nutricion (CIBEROBN), Malaga, Spain, 4 Servicio de Cirugıa, Hospital Clınico Virgen de la Victoria, Malaga, Spain, 5 Fundacion IMABIS, Malaga, Spain Abstract Objective: De novo lipogenesis is involved in fatty acid biosynthesis and could be involved in the regulation of the triglyceride storage capacity of adipose tissue. However, the association between lipogenic and lipolytic genes and the evolution of morbidly obese subjects after bariatric surgery remains unknown. In this prospective study we analyze the association between the improvement in the morbidly obese patients as a result of