the association of cysteine with obesity, inflammatory cytokines and insulin resistance in hispanic children and adolescents半胱氨酸的协会与肥胖、炎症细胞因子和胰岛素抵抗在西班牙裔儿童和青少年.pdf

The Association of Cysteine with Obesity, Inflammatory Cytokines and Insulin Resistance in Hispanic Children and Adolescents 1,2 1 1,3. 4. Amany K. Elshorbagy *, Maria Valdivia-Garcia , Helga Refsum , Nancy Butte 1 Department of Pharmacology, University of Oxford, Oxford, United Kingdom, 2 Department of Physiology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt, 3 Institute of Basic Medical Sciences, Department of Nutrition, University of Oslo, Oslo, Norway, 4 USDA/ARS Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America Abstract Context: Plasma total cysteine (tCys) independently relates to fat mass in adults. Dietary cyst(e)ine promotes adiposity and decreases glucose tolerance in some rodent models, but alleviates insulin resistance in others. Objective: To investigate whether the association of tCys with body fat extends to children at particular risk of obesity, and whether tCys is associated with insulin resistance and obesity-associated inflammation. Methods: We explored the cross-sectional relations of fasting plasma tCys and related metabolites with body composition measured by dual-energy X-ray absorptiometry in 984 Hispanic children and adolescents aged 4–19 years from the Viva La Familia Study. Linear and logistic regression and dose-response curves were used to evaluate relations of tCys with obesity, insulin resistance and inflammatory markers including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-a), monocyte chemoattractant protein-1 (MCP-1) and C-reactive protein (CRP). Results: tCys, methionine and total homocysteine (tHcy) increased with age. Upper tCys quartile was independently associate