the baboon (papio spp.) as a model of human ebola virus infection狒狒(papio spp。)作为人类埃博拉病毒感染模型.pdf

Viruses 2012, 4, 2400-2416; doi:10.3390/v4 102400 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Review The Baboon (Papio spp.) as a Model of Human Ebola Virus Infection Donna L. Perry 1,*, Laura Bollinger 1 and Gary L.White 2 1 Integrated Research Facility, Division of Clinical Research, NIAID, NIH, Frederick, MD, USA; E-Mail: bollingerl@ 2 Department of Pathology, University of Oklahoma Baboon Research Resource, University of Oklahoma, Ft. Reno Science Park, OK, USA; E-Mail: gary-white@ * Author to whom correspondence should be addressed; E-Mail: perrydl@; Tel.: +1-301-631-7249; Fax: +1-301-619-5029. Received: 8 October 2012; in revised form: 17 October 2012 / Accepted: 17 October 2012 / Published: 23 October 2012 Abstract: Baboons are susceptible to natural Ebola virus (EBOV) infection and share 96% genetic homology with humans. Despite these characteristics, baboons have rarely been utilized as experimental models of human EBOV infection to evaluate the efficacy of prophylactics and therapeutics in the United States. This review will summarize what is known about the pathogenesis of EBOV infection in baboons compared to EBOV infection in humans and other Old World nonhuman primates. In addition, we will discuss how closely the baboon model recapitulates human EBOV infection. We will also review some of the housing requirements and behavioral attributes of baboons compared to other Old World nonhuman primates.