the complexity of antibody-dependent enhancement of dengue virus infection锁定的复杂性增强登革热病毒感染.pdf

Viruses 2010, 2, 2649-2662; doi:10.3390/v2122649 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Commentary The Complexity of Antibody-Dependent Enhancement of Dengue Virus Infection Maria G. Guzman * and Susana Vazquez Department of Virology, PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, “Pedro Kouri” Tropical Medicine Institute of Havana, Cuba; E-Mail: ciipk@ipk.sld.cu * Author to whom correspondence should be addressed; E-Mail: lupe@ipk.sld.cu; Tel.: +53-7-2020450; Fax: +53-7-2046051. Received: 25 October 2010; in revised form: 22 November 2010 / Accepted: 22 November 2010 / Published: 8 December 2010 Abstract: Antibody-dependent enhancement (ADE) has been proposed as a mechanism to explain dengue hemorrhagic fever (DHF) in the course of a secondary dengue infection. Very recently, Dejnirattisai et al., 2010 [1], published an important article supporting the involvement of anti-prM antibodies in the ADE phenomenon. The complexity of ADE in the context of a secondary dengue infection is discussed here. Keywords: dengue; dengue hemorrhagic fever; prM; ADE; neutralization; cleavage 1. Introduction A rapid increase in dengue reports has been observed in the last three decades. Today, dengue infections are a serious cause of morbidity and mortality in most tropical and subtropical regions of the world: an estimated 50– 100 million people are infected annually and over 2.5 billion people live in endemic areas; and more than 100 countries are at risk for dengue transmission.