the human antibody response to dengue virus infection登革病毒感染的人类抗体反应.pdf

Viruses 2011, 3, 2374-2395; doi:10.3390/v3122374 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Review The Human Antibody Response to Dengue Virus Infection Wahala M. P. B. Wahala and Aravinda M. de Silva * Department of Microbiology and Immunology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA; E-Mails: wahala@ * Author to whom correspondence should be addressed; E-Mail: desilva@; Tel.: +1-919-843-9964; Fax: +1-919-962-8103. Received: 11 October 2011; in revised form: 12 November 2011 / Accepted: 15 November 2011 / Published: 25 November 2011 Abstract: Dengue viruses (DENV) are the causative agents of dengue fever (DF) and dengue hemorrhagic fever (DHF). Here we review the current state of knowledge about the human antibody response to dengue and identify important knowledge gaps. A large body of work has demonstrated that antibodies can neutralize or enhance DENV infection. Investigators have mainly used mouse monoclonal antibodies (MAbs) to study interactions between DENV and antibodies. These studies indicate that antibody neutralization of DENVs is a “multi-hit” phenomenon that requires the binding of multiple antibodies to neutralize a virion. The most potently neutralizing mouse MAbs bind to surface exposed epitopes on domain III of the dengue envelope (E) protein. One challenge facing the dengue field now is to extend these