targeting antibody responses to the membrane proximal external region of the envelope glycoprotein of human immunodeficiency virus针对抗体反应膜近端外部地区人类免疫缺陷病毒的包膜糖蛋白.pdf

Targeting Antibody Responses to the Membrane Proximal External Region of the Envelope Glycoprotein of Human Immunodeficiency Virus 1 1 1 1 Donatien Kamdem Toukam , Matthias Tenbusch , Alexander Stang , Vladimir Temchura , 1 1 2 3 Michael Storcksdieck genannt Bonsmann , Bastian Grewe , Stefanie Koch , Andreas Meyerhans , 4 5 ¨ 1 Godwin Nchinda , Lazare Kaptue , Klaus Uberla * 1 Department of Molecular and Medical Virology, Ruhr-University Bochum, Bochum, Germany, 2 Fraunhofer Institute for Biomedical Engineering, Sulzbach, Germany, 3 ICREA Infection Biology Laboratory, Department of Experimental and Health Sciences, University Pompeu Fabra, Barcelona, Spain, 4 Laboratory of Immunology, The ´ Chantal Biya International Reference Centre for Research on HIV/AIDS Prevention and Management (CIRCB), Yaounde, Cameroon, 5 Institut Superieur des Sciences de la ´ ´ ´ Sante, Universite des Montagnes, Bangante, Cameroon Abstract Although human immunodeficiency type 1 (HIV-1) infection induces strong antibody responses to the viral envelope glycoprotein (Env) only a few of these antibodies possess the capacity to neutralize a broad range of strains. The induction of such antibodies represents an important goal in the development of a preventive vaccine against the infection. Among the broadly neutralizing monoclonal antibodies discovered so far, three (2F5, Z13 and 4E10) targ