the disulfide bonds in glycoprotein e2 of hepatitis c virus reveal the tertiary organization of the molecule二硫键的丙型肝炎病毒的糖蛋白e2揭示的三级组织分子.pdf

The Disulfide Bonds in Glycoprotein E2 of Hepatitis C Virus Reveal the Tertiary Organization of the Molecule 1 2 1 3 1 Thomas Krey , Jacques d’Alayer , Carlos M. Kikuti , Aure Saulnier , Laurence Damier-Piolle , Isabelle 4 5¤ 1 6 7 6 Petitpas , Daniel X. Johansson , Rajiv G. Tawar , Bruno Baron , Bruno Robert , Patrick England , 5 3 ´ 1 Mats A. A. Persson , Annette Martin , Felix A. Rey * ´ ´ ´ 1 Institut Pasteur, CNRS URA3015, Unite de Virologie Structurale, Paris, France, 2 Institut Pasteur, Plate-forme d’Analyse et de Microsequenc¸age des Proteines, Paris, France, ´ ´ ´ ´ ` ´ 3 Institut Pasteur, CNRS URA3015, Unite de Genetique Moleculaire des Virus a ARN, Paris, France, 4 CNRS UPR3296, Laboratoire de Virologie Moleculaire et Structurale, Gif- sur-Yvette, France, 5 Karolinska University Hospital, Department of Medicine, Center for Molecular Medicine, Stockholm, Sweden, 6 Institut Pasteur, CNRS URA2185, Plate- ´ forme de Biophysique des Macromolecules et de leurs Interactions, Paris, France, 7 CEA, CNRS URA2096, Institut de Biologie et de Technologie de Saclay, Gif-sur-Yvette, France Abstract Hepatitis C virus (HCV), a major cause of chronic liver disease in humans, is the focus of intense research efforts w