the cd81 partner ewi-2wint inhibits hepatitis c virus entry研究合作伙伴ewi-2wint抑制丙型肝炎病毒条目.pdf

The CD81 Partner EWI-2wint Inhibits Hepatitis C Virus Entry 1. 1. 1 1 1 Vera Rocha-Perugini , Claire Montpellier , David Delgrange , Czeslaw Wychowski , Franc¸ois Helle , ´ 1 ´ 1 3 ´ 3 2 Andre Pillez , Herve Drobecq , Franc¸ois Le Naour , Stephanie Charrin , Shoshana Levy , Eric 3 1 1,2 Rubinstein , Jean Dubuisson *, Laurence Cocquerel * ´ 1 Institut de Biologie de Lille (UMR8161), CNRS, Universites de Lille I et Lille II, Institut Pasteur de Lille, Lille, France, 2 Division of Oncology, Department of Medicine, ´ ´ ˆ Stanford University Medical Center, Stanford, California, United States of America, 3 INSERM-U602, Institut Andre-Lwoff, Universite Paris XI, Hopital Paul Brousse, Villejuif, France Abstract Two to three percent of the world’s population is chronically infected with hepatitis C virus (HCV) and thus at risk of developing liver cancer. Although precise mechanisms regulating HCV entry into hepatic cells are still unknown, several cell surface proteins have been identified as entry factors for this virus. Among these molecules, the tetraspanin CD81 is essential for HCV entry. Here, we have identified a partner of CD81, EWI-2wint, which is expressed in several cell lines but not in hepatocytes. Ectopic expression of EWI-2wint