temperature shift and host cell contact up-regulate sporozoite expression of plasmodium falciparum genes involved in hepatocyte infection温度变化和宿主细胞接触调控的孢子体的表达恶性疟原虫基因在肝细胞的感染.pdf

Temperature Shift and Host Cell Contact Up-Regulate Sporozoite Expression of Plasmodium falciparum Genes Involved in Hepatocyte Infection Anthony Siau1,2, Olivier Silvie1,2.¤, Jean-Franc¸ois Franetich1,2., Samir Yalaoui1,2, Carine Marinach1,2, 3 4 4 5 6 Laurent Hannoun , Geert-Jaan van Gemert , Adrian J. F. Luty , Emmanuel Bischoff , Peter H. David , Georges Snounou7, Catherine Vaquero1,2, Patrick Froissard 1,2, Dominique Mazier1,2,8* ´ ´ ´ 1 INSERM, U511, Paris, France, 2 Universite Pierre et Marie Curie-Paris 6, UMR S511 Paris, France, 3 Service de Chirurgie Digestive, Hepato-Bilio-Pancreatique et ´ ˆ ´ ˆ ` Transplantation Hepatique, Hopital Pitie-Salpetriere, Paris, France, 4 Department of Medical Microbiology, University Medical Centre, Nijmegen, The Netherlands, 5 PF2- ´ ´ ´ Genopole, Institut Pasteur, Paris France, 6 Unite d’Immunologie Moleculaire des Parasites, CNRS URA 2581, Departement de Parasitologie, Institut Pasteur, Paris, France, ´ ` ´ ´ ´ ˆ ` 7 Laboratoire de Parasitologie Comparee et Modeles Experimentaux, Museum National d’Histoire Naturelle, Paris, France, 8 AP-HP, Groupe hospitalier Pitie-Salpetriere, Service Parasitologie-Mycologie, Paris, France Abstract Plasmodium sporozoites are deposited in the skin by Anopheles mosquitoes. They then find their way to the liver