conserved mosquitoparasite interactions affect development of plasmodium falciparum in africa守恒mosquitoparasite交互影响恶性疟原虫在非洲的发展.pdf

Conserved Mosquito/Parasite Interactions Affect Development of Plasmodium falciparum in Africa 1. 1. 2 3 4 Antonio M. Mendes , Timm Schlegelmilch , Anna Cohuet , Parfait Awono-Ambene , Maria De Iorio , 2 3 1 1 1 Didier Fontenille , Isabelle Morlais , George K. Christophides , Fotis C. Kafatos *, Dina Vlachou * 1 Imperial College London, Division of Cell and Molecular Biology, Faculty of Natural Sciences, South Kensington Campus, London, United Kingdom, 2 Institut de ´ Recherche pour le Developpement - Laboratoire de Lutte contre les Insectes Nuisibles, UR 016, BP 64501, Montpellier, France, 3 Organisation de Coordination de la lutte ´ ´ contre les Endemies en Afrique Centrale, Laboratoire de Recherche sur le Paludisme, BP 288, Yaounde, Cameroon, 4 Imperial College London, Division of Epidemiology, Department of Public Health and Primary Care, Faculty of Medicine, St Mary’s Campus, London, United Kingdom Abstract In much of sub-Saharan Africa, the mosquito Anopheles gambiae is the main vector of the major human malaria parasite, Plasmodium falciparum. Convenient laboratory studies have identified mosquito genes that affect positively or negatively the developmental cycle of the model rodent parasite, P. berghei. Here, we use transcription profiling and reverse genetics to explore whether five disparate mosquito gene regulators of P. berghei development are also pertinent to A. gambiae/P. falciparum interactions in