universal features of post-transcriptional gene regulation are critical for plasmodium zygote development转录后基因调控的普遍特征为疟原虫受精卵发展至关重要.pdf
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Universal Features of Post-Transcriptional Gene
Regulation Are Critical for Plasmodium Zygote
Development
1,2 3 4¤ 1 ´
Gunnar R. Mair *, Edwin Lasonder , Lindsey S. Garver , Blandine M. D. Franke-Fayard , Celine K.
2 5 5 4 1
Carret , Joop C. A. G. Wiegant , Roeland W. Dirks , George Dimopoulos , Chris J. Janse , Andrew P.
Waters1,6*
1 Leiden Malaria Research Group, Department of Parasitology, Centre for Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands, 2 Instituto de
Medicina Molecular, Unidade de Parasitologia Molecular, Lisboa, Portugal, 3 Centre for Molecular and Biomolecular Informatics, NCMLS, Radboud University Nijmegen
Medical Centre, Nijmegen, The Netherlands, 4 W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public
Health, Baltimore, Maryland, United States of America, 5 Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands, 6 Division of
Infection and Immunity, Faculty of Biomedical Life Sciences, and Wellcome Centre for Molecular Parasitology, Glasgow Biomedical Research Centre, University of Glasgow,
Glasgow, Scotland, United Kingdom
Abstract
A universal feature of metazoan sexual development is the generation of oocyte P granules that withhold certain mRNA
species from translation to provide coding potential for proteins during early post-fertilization development. Stabilisation of
translationally quiescent mRNA pools in female Plasmodium gametocytes depends on the RNA helicase DOZI, but the
molecular machinery involved in the silencing of transc
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