c. elegans atad-3 is essential for mitochondrial activity and development秀丽隐杆线虫atad-3线粒体活动和发展至关重要.pdf

C. elegans ATAD-3 Is Essential for Mitochondrial Activity and Development 1,2 ` 3 3 4,5 Michael Hoffmann , Nadege Bellance , Rodrigue Rossignol , Werner J. H. Koopman , Peter H. G. M. 4,5 1 6 1 Willems , Ertan Mayatepek , Olaf Bossinger *, Felix Distelmaier * ¨ 1 Department of General Pediatrics, University Children’s Hospital, Heinrich-Heine-University, Dusseldorf, Germany, 2 Institute for Genetics, Heinrich-Heine-University, ¨ ´ ´ Dusseldorf, Germany, 3 Institut National de la Sante et de la Recherche Medicale (INSERM), U688 Physiopathologie Mitochondriale, Universite Victor Segalen-Bordeaux 2, Bordeaux, France, 4 Department of Biochemistry, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, 5 Microscopical Imaging Center, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, 6 Institute of Molecular and Cellular Anatomy, RWTH Aachen University, Aachen, Germany Abstract Background: Mammalian ATAD3 is a mitochondrial protein, which is thought to play an important role in nucleoid organization. However, its exact function is still unresolved. Results: Here, we characterize the Caenorhabditis elegans (C. elegans) ATAD3 homologue (ATAD-3) and investigate its importance for mitochondrial function and development. We show that ATAD-3 is highly conserved among diffe