the amelioration of renal damage in skp2-deficient mice canceled by p27 kip1 deficiency in skp2？？ p27？？ mice肾损害的改善skp2-deficient老鼠取消由p27 kip1缺乏skp2 p27 老鼠.pdf

The Amelioration of Renal Damage in Skp2-Deficient Mice Canceled by p27 Kip1 Deficiency in Skp22/ 2 p272/ 2 Mice 1 2 2¤ 2 2 1 Sayuri Suzuki , Hirotaka Fukasawa , Taro Misaki , Akashi Togawa , Naro Ohashi , Kyoko Kitagawa , 1 1 1 3 4 2,5 Yojiro Kotake , Ning Liu , Hiroyuki Niida , Keiko Nakayama , Keiichi I. Nakayama , Tatsuo Yamamoto , Masatoshi Kitagawa1* 1 Department of Molecular Biology, Hamamatsu University School of Medicine, Hamamatsu, Japan, 2 First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan, 3 Division of Developmental Genetics, Center for Translational and Advanced Animal Research on Human Diseases, Tohoku University Graduate School of Medicine, Sendai, Japan, 4 Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan, 5 Second Department of Medicine, Numazu City Hospital, Numazu, Japan Abstract SCF-Skp2 E3 ubiquitin ligase (Skp2 hereafter) targets several cell cycle regulatory proteins for degradation via the ubiquitin- dependent pathway. However, the target-specific physiological functions of Skp2 have not been fully elucidated in kidney diseases. We previously reported an increase in Skp2 in progressive nephropathy and amelioration of unilateral ureteral obstruction (UUO) renal injury associated with renal accumulation of p27 in Skp22/ 2 mice. However, it remains unclear whether the amelioration of renal injury in Skp22/ 2 mice is solely caused