the biology of autoimmune response in the scurfy mice that lack the cd4+foxp3+ regulatory t-cells自身免疫反应的生物学皮屑老鼠缺乏cd4 + foxp3 +调控t细胞.pdf

Biology 2012, 1, 18-42; doi:10.3390/biology1010018 OPEN ACCESS biology ISSN 2079-7737 /journal/biology Article The Biology of Autoimmune Response in the Scurfy Mice that Lack the CD4+ + Foxp3 Regulatory T-Cells Shyr-Te Ju 1,2,3,*, Rahul Sharma 1,2, Felicia Gaskin 4, John T. Kung 5,6 and Shu Man Fu 1,2,3,* 1 Center for Immunity, Inflammation and Regenerative Medicine, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA 2 Department of Medicine, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA 3 Department of Microbiology, Immunology, and Cancer, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA 4 Department of Psychiatry and Neurobehavioral Sciences, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA 5 Academia Sinica, Nankang District, Taipei 11529, Taiwan 6 Department of Immunology, School of Medicine, National Taiwan University, Taipei 10051, Taiwan * Authors to whom correspondence should be addressed; E-Mails: sj8r@ (S.-T.J.); sf2e@ (S.M.F.). Received: 2 March 2012; in revised form: 22 March 2012 / Accepted: 26 March 2012 / Published: 4 April 2012 Abstract: Due to a mutation in the Foxp3 transcription factor, Scurfy mice lack regulatory T-cells that maintain self-tolerance of the immune system. They develop multi-organ inflammation (MOI) and die around four weeks old. The affected organs are skin, tail, lungs and liver. In humans, endocr