the circumventricular organs participate in the immunopathogenesis of experimental autoimmune encephalomyelitiscircumventricular器官参与实验性自身免疫性脑脊髓炎的免疫发病机理.pdf

Cerebrospinal Fluid Research BioMed Central Research Open Access The circumventricular organs participate in the immunopathogenesis of experimental autoimmune encephalomyelitis 2 1,2,3 Martina Schulz and Britta Engelhardt* 1 2 Address: Theodor Kocher Institute, University of Bern, CH-3012 Bern, Switzerland, Kerckhoff Institute, Department of Vascular Biology, Bad Nauheim, Germany and 3Max-Planck Institute for Molecular Biomedicine, Münster, Germany Email: Martina Schulz - Martina_Schulz@t-online.de; Britta Engelhardt* - bengel@tki.unibe.ch * Corresponding author Published: 30 September 2005 Received: 15 July 2005 Accepted: 30 September 2005 Cerebrospinal Fluid Research 2005, 2:8 doi:10.1186/1743-8454-2-8 This article is available from: /content/2/1/8 © 2005 Schulz and Engelhardt; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: During inflammatory conditions of the central nervous system (CNS), such as in multiple sclerosis or in its animal model, experimental autoimmune encephalomyelitis (EAE), immune cells migrate from the blood stream into the CNS parenchyma and into the cerebrospinal fluid (CS