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baff promotes th17 cells and aggravates experimental autoimmune encephalomyelitis高飞球的一击促进实验性自身免疫性脑脊髓炎th17细胞和加剧.pdf

发布:2017-08-27约6.44万字共10页下载文档
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BAFF Promotes Th17 Cells and Aggravates Experimental Autoimmune Encephalomyelitis 1,2. 1. 1,2 1 1,3 4 2 Xiaohui Zhou , Zanxian Xia , Qin Lan , Julie Wang , Wenru Su , Yuan-Ping Han , Huimin Fan , 2 1 1 Zhongmin Liu , William Stohl * , Song Guo Zheng * 1 Division of Rheumatology, Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America, 2 Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China, 3 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guanzhou, China, 4 Department of Surgery, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America Abstract Background: BAFF, in addition to promoting B cell survival and differentiation, may affect T cells. The objective of this study was to determine the effect of BAFF on Th17 cell generation and its ramifications for the Th17 cell-driven disease, EAE. Methodology/Principal Findings: Th17 cells were increased in BAFF-Tg B6 (B6.BTg) mice and decreased in B6.Baff2/ 2 mice. Th17 cells in B6.Baff2/ 2 mice bearing a BAFF Tg (B6.Baff2/ 2.BTg mice) were identical to those in B6.BTg mice, indicating that membrane BAFF is dispensable for Th17 cell generation as long as soluble BAFF is plentiful. In T + non-T cell criss-cross co- cultures, Th17 cell generation was greatest in cultures containing B6.BTg T cells and lowest in cultures containing B6.Baff2/ 2 T cells, regardless of the source of non-T cells. In cultures containing only T cells, Th17 cell generation followed an identical patte
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