synthesis and total 1h- and 13c-nmr assignment of cephem derivatives for use in adept approaches合成和总1 h -和色谱仪转让cephem衍生品在熟练的使用方法.pdf

Molecules 2008, 13, 841-854 molecules ISSN 1420-3049 © 2008 by MDPI /molecules Full Paper Synthesis and Total 1H- and 13C-NMR Assignment of Cephem Derivatives for Use in ADEPT Approaches 1 1 2 3 Lorena Blau , Renato Farina Menegon , Elizabeth Igne Ferreira , Antonio Gilberto Ferreira , Elisangela Fabiana Boffo 3, Leila Aley Tavares 3, Vladimir Constantino Gomes Heleno 3,4,* and Man-Chin Chung 1,* 1 Departamento de Fármacos e Medicamentos, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista, CP 502 – 14801-902, Araraquara, SP, Brazil; E-mails: lorenblau@; renato.farina@ 2 Departamento de Farmácia, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, CP 66083 – 05389-970, São Paulo, SP, Brazil; E-mail: hajudan@usp.br 3 Departamento de Química, Centro de Ciências Exatas e Tecnológicas, Universidade Federal de São Carlos, CP 676 – 13565-905, São Carlos, SP, Brazil; E-mails: giba_04@.br; efboffo@.br; leilaley@ 4 Núcleo de Pesquisas em Ciências Exatas e Tecnológicas – Universidade de Franca, CP 82 – 14404- 600, Franca, SP, Brazil * Authors to whom correspondence should be addressed; E-mail for V.C.G.H.: heleno.vcg@unifran.br; Phone: +55 16 Fax: +55 16 E-mail for M-C.C.: chungmc@fcfar.unesp.br; Phone: +55 16 Fax: +55 16 Received: 12 March 2008; in revised form: 6 April 2008 / Accepted: 7 April 2008 / Published: 10 April 2008 Abstract: We report the synthesis and total NMR characterization o