synthesis, ftir, 13c-nmr and temperature-dependent 1h？nmr characteristics of bis-naphthalimide derivatives合成、红外光谱与温度有关的色谱仪、1 h bis-naphthalimide衍生品的核磁共振特征.pdf

Molecules 2012, 17, 12427-12448; doi:10.3390/molecules171012427 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis, FTIR, 13C-NMR and Temperature-Dependent 1H-NMR Characteristics of Bis-naphthalimide Derivatives Waldemar Grzesiak and Bogumił Brycki * Laboratory of Microbiocides Chemistry, Department of Chemistry, Adam Mickiewicz University, Grunwaldzka 6, 60-780 Poznań, Poland * Author to whom correspondence should be addressed; E-Mail: brycki@.pl; Tel.: +48-61-829-1314; Fax: +48-61-829-1505. Received: 5 September 2012; in revised form: 17 October 2012 / Accepted: 18 October 2012 / Published: 22 October 2012 Abstract: Chemotherapy is still the most important method of cancer treatment. To make this method more effective and safe, new drugs to destroy cancer cells are needed. Some bis-naphthalimide derivatives show potential anticancer activity via an intercalation mechanism. A higher degree of DNA intercalation corresponds to better therapeutic effects. The degree of intercalation of naphthalimides depends on their structure, molecular dynamics and intermolecular interactions with DNA. In order to apply any active substance as a drug, its molecular dynamics as well as possible interactions with target molecules have to be examined in exhaustive details. This paper describes a practical preparation of some novel bis-naphthalimide derivatives with different functional groups and their FTIR and 1H- and 13C-NMR spectral characteristics. To det