solid-phase synthesis of arylpiperazine derivatives and implementation of the distributed drug discovery (d3) project in the search for cns agents固相合成arylpiperazine衍生品和实现分布式的药物发现中枢神经系统(d3)项目在寻找代理.pdf

Molecules 2011, 16, 4104-4121; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Solid-Phase Synthesis of Arylpiperazine Derivatives and Implementation of the Distributed Drug Discovery (D3) Project in the Search for CNS Agents Paweł Zajdel 1,*, Joanna Król 1, Katarzyna Grychowska 1, Maciej Pawłowski 1, Gilles Subra 2, Gaël Nomezine 2, Jean Martinez 2, Grzegorz Satała 3, Andrzej J. Bojarski 3, Ziniu Zhou 4, Martin J. O’Donnell 4 and William L. Scott 4,* 1 Department of Medicinal Chemistry, Jagiellonian University Medical College, 9 Medyczna Street, Kraków 30-688, Poland 2 Équipe Aminoacides Peptides et Protéines, Institut des Biomolécules Max Mousseron IBMM, UMR CNRS 5247, Faculté de Pharmacie, Université Montpellier I et II, 15 avenue Charles Flahault, Montpellier 34060, France 3 Department of Medicinal Chemistry, Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, Kraków 31-343, Poland 4 Department of Chemistry and Chemical Biology, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202, USA * Authors to whom correspondence should be addressed; E-Mails: mfzajdel@.pl (P.Z.); wscott@ (W.L.S.). Received: 13 April 2011; in revised form: 14 May 2011 / Accepted: 16 May 2011 / Published: 19 May 2011 Abstract: We have successfully implemented the concept of Distributed Drug Discovery (D3) in the search for CNS agents. Herein, we demonstrate, for the first time, student engagement from different sites around the globe in the development of new