synthesis and evaluation of new β-carboline-3-(4-benzylidene)-4h-oxazol-5-one derivatives as antitumor agents(合成和评估新的β-carboline-3)- 4-benzylidene 4 h-oxazol-5-one衍生品作为抗肿瘤剂.pdf

Molecules 2012, 17, 6100-6113; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis and Evaluation of New β-Carboline-3-(4-benzylidene)- 4H-oxazol-5-one Derivatives as Antitumor Agents Franciele Cristina Savariz 1, Mary Ann Foglio 2, João Ernesto de Carvalho 2, Ana Lúcia T. G. Ruiz 2, 2 3 1 Marta C. T. Duarte , Mauricio Ferreira da Rosa , Emerson Meyer and Maria Helena Sarragiotto 1,* 1 Departamento de Química, Centro de Ciências Exatas, Universidade Estadual de Maringá, Av. Colombo, 5790, Maringá, 87020-900 PR, Brazil 2 Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA), Universidade Estadual de Campinas, 6171, Campinas, 13083-970 SP, Brazil 3 Centro de Engenharias e Ciências Exatas, Universidade Estadual do Oeste do Paraná, Rua da Faculdade, 645, Toledo, 85903-000 PR, Brazil * Author to whom correspondence should be addressed; E-Mail: mhsarragiotto@uem.br; Tel.: +55-44-3261-3657; Fax: +55-44-3011-4125. Received: 5 April 2012; in revised form: 5 May 2012 / Accepted: 7 May 2012 / Published: 21 May 2012 Abstract: In the present work, we report the synthesis and in vitro anticancer and antimicrobial activity evaluation of a new series of 1-substituted-β-carboline derivatives bearing a 4-benzylidene-4H-oxazol-5-one unity at C-3. The compound 2-[1-(4- methoxyphenyl)-9H-β-carbolin-3-yl]-4-(benzylidene)-4H-oxazol-5-on