synthesis and antibacterial evaluation of new n-acylhydrazone derivatives from dehydroabietic acid合成和抗菌的评估新n-acylhydrazone衍生品脱氢枞酸.pdf

Molecules 2012, 17, 4634-4650; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis and Antibacterial Evaluation of New N-acylhydrazone Derivatives from Dehydroabietic Acid Wen Gu *, Rongrong Wu, Shilong Qi, Chenhai Gu, Fanjunnan Si and Zhuhui Chen College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China * Author to whom correspondence should be addressed; E-Mail: njguwen@163.com; Tel.: +86-25-8542-8369. Received: 26 March 2012; in revised form: 1 April 2012 / Accepted: 5 April 2012 / Published: 20 April 2012 Abstract: A series of new N-acylhydrazone derivatives were synthesized in good yields through the reactions of dehydroabietic acid hydrazide with a variety of substituted arylaldehydes. The structures of the synthesized compounds were confirmed by IR, 1H- and 13C-NMR, ESI-MS, elemental analysis and single crystal X-ray diffraction. From the crystal structure of compound 4l, the C=N double bonds of these N-acylhydrazones showed (E)-configuration, while the NMR data of compounds 4a–q indicated the existence of two rotamers for each compound in solution. The target compounds were evaluated for their antibacterial activities against four microbial strains. The result suggested that several compounds exhibited pronounced antibacterial activities. Particularly, compound 4p exhibited good antibacterial activity against Staphylococcus aureus and Bacillus