血清肌红蛋白-尿酸-脑钠肽及慢性心力衰竭相关性探究.doc

血清肌红蛋白\尿酸\脑钠肽及慢性心力衰竭相关性探究[摘要] 目的：探讨血清肌红蛋白、尿酸、脑钠肽与慢性心力衰竭的相关性。方法：选取2005年1月~2010年8月于本院进行治疗的128例慢性心力衰竭患者为观察组，同时选取同期的128名健康体检人员为对照组，后将两组人员的血清肌红蛋白、尿酸、脑钠肽水平进行检测及比较。结果：经过研究比较发现，观察组的血清肌红蛋白、尿酸、脑钠肽水平均显著高于对照组，且患者随NYHA分级增高，心功能越来越差，这些血清因子水平也越来越高，差异有统计学意义或高度统计学意义（P＜0.05或P＜0.01）。结论：血清肌红蛋白、尿酸、脑钠肽与慢性心力衰竭有极大的相关性，值得临床进一步研究及探讨。 [关键词] 肌红蛋白；尿酸；脑钠肽；慢性心力衰竭；相关性 [中图分类号] R541.6[文献标识码]A[文章编号]1673-7210（2011）03（b）-027-02 The study on the correction between serum myoglobin, uric acid, brain natriuretic peptide and chronic heart failure YU Hepeng, CHANG Jing, LUO Leiming, YE Ping Department of Geriatric Cardiology, PLA General Hospital, Beijing 100853 [Abstract] Objective: To study the correction between serum myoglobin, uric acid, brain natriuretic peptide and chronic heart failure. Methods: 128 patients with chronic heart failure in our hospital from January 2005 to August 2010 were selected as observation group, 128 healthy peoples at the same time were selected as control group, then the serum myoglobin, uric acid and brain natriuretic peptide of the two groups were detected and compared. Results: The serum myoglobin, uric acid and brain natriuretic peptide of observation group were significantly higher than those of control group, and cardiac function was worse and worse and these serum factors were higher and higher, there were significant differences or very significant differences (P＜0.05 or P＜0.01). Conclusion: There is big correction between serum myoglobin, uric acid, brain natriuretic peptide and chronic heart failure, and it should be studied and analyzed. [Key words] Myoglobin; Uric acid; Brain natriuretic peptide; Chronic heart failure; Correction 慢性心力衰竭是由各种疾病引起心肌收缩能力减弱，从而使心脏的血液输出量减少，不足以满足机体的需要，并由此产生一系列的症状和体征[1]。在此过程中患者机体的多项血清因子也随之发生变化，而对这些血清因子变化规律的研究对于疾病的诊治及了解疾病的预后均有着积极的意义[2]。本文就血清肌红蛋白、尿酸、脑钠肽与慢性心力衰竭的相关性进行研究，现将结果总结报道如下： 1 资料与方法 1.1 一般资料 选取2005年1月~2010年8月于本院进行治疗的128例慢性心力衰竭患者为观察组，同时选取同期的128名健康体检人员为对照组。对照组的128名健康人中，男74名，女54名；年龄40~76岁，平均（64.8±6.1）岁。观察组的12