冠心病心力衰竭患者血尿酸脑钠肽高敏-C反应蛋白与左室射血分数的相关性分析.doc

冠心病心力衰竭患者血尿酸、脑钠肽、高敏-C反应蛋白与左室射血分数的相关性分析 【摘要】目的：探讨冠心病心力衰竭（简称心衰）患者血尿酸、脑钠肽、高敏-C反应蛋白与左室射血分数的相关性。方法：选择我院心内科120例冠心病心衰患者作为观察组，纳入同期我院体检正常的120人作为对照组。检测两组患者血尿酸（UA）、脑钠肽(BNP)、高敏c-反应蛋白(hs-CRP)等水平，运用彩色多普勒超声进行左室射血分数（LVEF）功能测定，并进行相关性分析。结果：心衰组血浆UA、BNP、hs-CRP均较对照组显著升高，随着NYHY级别增高，血UA水平逐渐升高，其组间差异性显著(PO.O1)，与LVEF呈负相关(r=-0.69,PO.01)。BNP水平与NYHY有显著的相关性（r=0.64,PO.01），与LVEF呈负相关（r=-0.73,PO.01）。血hs-CPR随NYHA分级的增加而升高，但组间无显著性差异(r=0.165，P=0.068)，与LVEF(r=0.21，P=0.08)无关。结论：心力衰竭患者血浆UA、BNP和hs-CRP随着心力衰竭程度的加重而相应升高，UA、BNP与左室射血分数有良好的相关性，而hs-CRP则没有这种相关性。 【关键词】冠心病心力衰竭；血尿酸；脑钠肽；高敏-C反应蛋白；左室射血分数 【Abstract】Objective：To observe of coronary heart failure in patients with UA，BNP，hs-CRP and LVEF correlation．Methods：Cardiology in our hospital 120 cases of coronary heart disease in patients with heart failure as the observation group included normal physical examination in our hospital over the same period 120 as the control group. Were detected in patients with serum UA，BNP，hs-CRP and other levels，the use of color Doppler ultrasound for LVEF function test，and the correlation analysis．Results：Heart failure，plasma UA，BNP，hs-CRP were significantly higher than in the control group，with NYHY level increased，serum UA levels gradually increased，the difference between the groups was significantly（P0.01），negatively with LVEF correlation（r=- 0.69，P0.01）．BNP levels and NYHY significant correlation（r=0.64，P0.01），a negative correlation with LVEF（r=-0.73，P0.01）．Serum hs-CPR increases with NYHA class increased，but no significant group differences（r=0.165，P=0.068），and LVEF（r=0.21，P=0.08）has nothing to do．Conclusion：Heart failure patients with UA，BNP and hs-CRP with the severity of heart failure and the corresponding increase，UA，BNP and left ventricular ejection fraction have a good correlation，and hs-CRP is no such correlation． 【Keywords】Coronary heart；UA；BNP；hs-CRP；LVEF 冠心病心力衰竭是常见的危重症，长期以来的诊断及评价标准往往缺乏特异性和敏感性，容易产生过度诊断及漏诊。近年许多临床研究提示炎症和神经内分泌激素的激活在心力衰竭的发生和发展过程中起着重要作用，对患者进行血尿酸（UA）、脑钠肽(BNP)、高敏c-反应蛋白(hs-CRP)等生物标志进行检测及综合分析，发现其对冠