dedifferentiation of human primary thyrocytes into multilineage progenitor cells without gene introduction去分化的人类主要此外为multilineage祖细胞没有我们基因的介绍.pdf

Dedifferentiation of Human Primary Thyrocytes into Multilineage Progenitor Cells without Gene Introduction 1. 1,7 . 2 1 1 Keiji Suzuki , Norisato Mitsutake * , Vladimir Saenko , Masatoshi Suzuki , Michiko Matsuse , Akira 4 4 5 6 3 1,2,4 Ohtsuru , Atsushi Kumagai , Tatsuya Uga , Hiroshi Yano , Yuji Nagayama , Shunichi Yamashita 1 Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan, 2 Department of International Health and Radiation Research, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan, 3 Department of Medical Gene Technology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan, 4 Takashi Nagai Memorial International Hibakusha Medical Center, Nagasaki University Hospital, Nagasaki, Nagasaki, Japan, 5 Department of Transplantation and Digestive Surgery, Nagasaki University Hospital, Nagasaki, Nagasaki, Japan, 6 Division of Surgical Oncology, Department of Translational Medical Sciences, Nagasaki University Hospital, Nagasaki, Nagasaki, Japan, 7 Nagasaki University Research Centre for Genomic Instability and Carcinogenesis (NRGIC), Nagasaki, Nagasaki, Japan Abstract While identification and isolation of adult stem cells have potentially important implications, recent reports regarding dedifferentiation/reprogramming from differentiated cells have provided another clue to gain insight into source of tissue