cxcr4 expression in prostate cancer progenitor cells趋化因子受体cxcr4表达在前列腺癌的祖细胞.pdf

CXCR4 Expression in Prostate Cancer Progenitor Cells 1 ¤c 2 2 4 Anna Dubrovska * , Jimmy Elliott , Richard J. Salamone , Gennady D. Telegeev , Alexander E. 3 3 2 2 1¤b 1 Stakhovsky , Ihor B. Schepotin , Feng Yan , Yan Wang , Laure C. Bouchez , Sumith A. Kularatne , 2 2 1,2¤a 2 1 James Watson , Christopher Trussell , Venkateshwar A. Reddy , Charles Y. Cho , Peter G. Schultz * 1The Scripps Research Institute, La Jolla, California, United States of America, 2 Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America, 3 National Cancer Institute, Kyiv, Ukraine, 4 Institute of Molecular Biology and Genetics NAS of Ukraine, Kyiv, Ukraine Abstract Tumor progenitor cells represent a population of drug-resistant cells that can survive conventional chemotherapy and lead to tumor relapse. However, little is known of the role of tumor progenitors in prostate cancer metastasis. The studies reported herein show that the CXCR4/CXCL12 axis, a key regulator of tumor dissemination, plays a role in the maintenance of prostate cancer stem-like cells. The CXCL4/CXCR12 pathway is activated in the CD44+/CD133+ prostate progenitor population and affects differentiation potential, cell adhesion, clonal growth and tumorigenicity. Furthermore, prostate tumor xenograft studies in mice sho