the change and effect of endothelial progenitor cells in pig with multiple organ dysfunction syndromes内皮祖细胞的变化和影响猪与多器官功能障碍综合征.pdf

Available online /content/13/4/R118 Vol 13 No 4 Open Access Research The change and effect of endothelial progenitor cells in pig with multiple organ dysfunction syndromes Tian Hang Luo*, Yao Wang*, Zheng Mao Lu, Hong Zhou, Xu Chao Xue, Jian Wei Bi, Li Ye Ma and Guo En Fang Department of General Surgery, Changhai Hospital, The Second Military Medical University, Xiangyin Road, Shanghai 200433, PR China * Contributed equally Corresponding author: Guo En Fang, guoenfang@ Received: 16 Apr 2009 Revisions requested: 20 May 2009 Revisions received: 17 Jun 2009 Accepted: 15 Jul 2009 Published: 15 Jul 2009 Critical Care 2009, 13:R118 (doi:10.1186/cc7968) This article is online at: /content/13/4/R118 © 2009 Luo et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction The dysfunction and decrease of endothelial Results All the animals in the experimental group developed progenitor cells (EPCs) may play a very important role in the MODS (100%) and 17 of 20 animals (85%) died due to MODS; initiation of organ dysfunction caused by trauma or severe the incidence of MODS and death of the animals in the control sepsis. We aim to measure the number and function of EPCs in group were 0% (P 0.01). The number, migratory and adhesive the progression of multiple organ dysfunction syndromes capacities of EPCs decreased sharply in the animals of the (MODS)