suppression of ongoing experimental arthritis by a chinese herbal formula (huo-luo-xiao-ling dan) involves changes in antigen-induced immunological and biochemical mediators of inflammation英文论文.pdf

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2011, Article ID 642027, 10 pages doi:10.1155/2011/642027 Research Article Suppression of Ongoing Experimental Arthritis by a Chinese Herbal Formula (Huo-Luo-Xiao-Ling Dan) Involves Changes in Antigen-Induced Immunological and Biochemical Mediators of Inflammation Ying-Hua Yang,1 Rajesh Rajaiah,1 David Y.-W Lee,2 Zhongze Ma,2 Hua Yu,1 Harry H. S. Fong,3 Lixing Lao,4 Brian M. Berman,4 and Kamal D. Moudgil1 1 Department of Microbiology and Immunology, University of Maryland School of Medicine, HSF-1, Suite 380, 685 West Baltimore Street, Baltimore, MD 21201, USA 2 Mailman Research Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA 3 Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL 60612, USA 4 Center for Integrative Medicine, University of Maryland School of Medicine, East Hall, 520 W. Lombard St., Baltimore, MD 21201, USA Correspondence should be addressed to Kamal D. Moudgil, kmoud001@ Received 24 January 2010; Revised 20 June 2010; Accepted 1 September 2010 Copyright © 2011 Ying-Hua Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Rheumatoid arthritis (RA) is one of the major autoimmune diseases of global prevalence. The use of the anti-inflammatory drugs for the treatment of RA is associated with severe adverse reactions and toxicity. This limitation has necessitated the search for novel therapeutic products. We report here a traditional Chinese medicine-based herbal formula, Huo luo xiao ling dan (HLXL), which has potent antiar