suppression of in vitro and in vivo parameters of inflammatory synovitis by simvastatin抑制体外和体内参数辛伐他汀的炎性滑膜炎.pdf

Ishijima et al. Arthritis Research Therapy 2014, 16:R18 /content/16/1/R18 RESEARCH ARTICLE Open Access Intra-articular hyaluronic acid injection versus oral non-steroidal anti-inflammatory drug for the treatment of knee osteoarthritis: a multi-center, randomized, open-label, non-inferiority trial 1* 2 3 4 5 6 Muneaki Ishijima , Toshitaka Nakamura , Katsuji Shimizu , Kunihiko Hayashi , Hiraku Kikuchi , Satoshi Soen , 7 8 9 10 4 1 1 Go Omori , Toshihiko Yamashita , Yuji Uchio , Junji Chiba , Yuki Ideno , Mitsuaki Kubota , Hisashi Kurosawa , Kazuo Kaneko1 and for the Research Group of Cartilage Metabolism Abstract Introduction: While many of the commonly used conservative treatments for knee osteoarthritis (OA) have been recognized to be effective, there is still insufficient evidence available. Among the pharmacological treatments for knee OA, oral non-steroidal anti-inflammatory drugs (NSAIDs) act rapidly and are recommended for the management of OA. However, frequent and serious adverse effects of NSAIDs have been recognized. Intra-articular injections of hyaluronic acid (IA-HA) for the treatment of knee OA have been shown to reduce pain and improve joint function. However, there has been no qualified direct comparison study of the efficacy and safety between IA-HA and NSAIDs for patients with knee OA. The aim of this study was to clarify the efficacy and safety of early-phase IA-HA in comparison to those of NSAIDs for patients with knee OA. Methods: This multicenter, randomized, open-label, parallel-group, non-inferiority comparison study with an oral NSA