the clinical use of biomarkers as prognostic factors in ewing sarcoma生物标志物的临床使用尤因肉瘤的预后因素.pdf

van Maldegem et al. Clinical Sarcoma Research 2012, 2:7 /content/2/1/7 CLINICAL SARCOMA RESEARCH SHORT REPORT Open Access The clinical use of biomarkers as prognostic factors in Ewing sarcoma 1 3 1,2* Annmeik M van Maldegem , Pancras CW Hogendoorn and Andrew B Hassan Abstract Ewing Sarcoma is the second most common primary bone sarcoma with 900 new diagnoses per year in Europe (EU27). It has a poor survival rate in the face of metastatic disease, with no more than 10% survival of the 35% who develop recurrence. Despite the remaining majority having localised disease, approximately 30% still relapse and die despite salvage therapies. Prognostic factors may identify patients at higher risk that might require differential therapeutic interventions. Aside from phenotypic features, quantitative biomarkers based on biological measurements may help identify tumours that are more aggressive. We audited the research which has been done to identify prognostic biomarkers for Ewing sarcoma in the past 15 years. We identified 86 articles were identified using defined search criteria. A total of 11,625 patients were reported, although this number reflects reanalysis of several cohorts. For phenotypic markers, independent reports suggest that tumour size 8 cm and the presence of metastasis appeared strong predictors of negative outcome. Good histological response (necrosis 90%) after treatment appeared a significant predictor for a positive outcome. However, data proposing biological biomarkers for practical clinical use remain un-validated with only one secondary report published. Our recommendation is that we can stratify patients according to their stage and usi