Table 1 Identification of urinary biomarkers in JS cases在JS例尿生物标志物的鉴定1表.doc

Table 1. Clinical characteristics of the subjects at baseline Samples JS YAH YIH Control Sample No. 20 19 14 12 Age 48±6 46±10 51±7 45±6 Sex (F/M) 9/11 10/9 7/7 6/6 BMI(kg/m2) 22.7±2.96 23.8±1.68 25.71±2.84 22.64±2.51 ALT (U/L) 168.85±142.15 146.29±123.78 131.37±109.12 74.89±65.02 AST (U/L) 133.23±81.56 127.16±102.37 156.68±114.97 95.31±73.31 Total bilirubin (mg/dL) 4.05±2.64 4.52±2.41 3.97±3.16 1.26±1.19 Direct bilirubin(mg/dL) 2.53±1.83 3.56±2.66 2.73±1.92 1.41 ± 1.33 Indirect bilirubin(mg/dL) 1.47±1.13 1.44±1.09 1.35±0.51 0.76 ± 0.35 Table 2. Identification of urinary biomarkers in JS cases. Rt [M+H]+ [M-H]- Formula Name P-value 1.85 184.1916 C9H13NO3 Epinephrine 0.03 0.41 228.2365 C9H13N3O4 Deoxycytidine 0.01 1.15 262.3297 C11H19NO6 Methylglutarylcarnitine 0.02 3.42 247.1059 C12H22O5 3-Hydroxydodecanedioic acid 0.05 5.58 149.2452 C9H8O2 Cinnamic acid 0.00 1.18 223.1942 C10H9NO5 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid 0.00 1.96 181.2324 C9H12N2O2 Tyrosinamide 0.00 2.11 227.2702 C10H14N2O4 Porphobilinogen 0.02 7.64 289.4044 C18H24O3 16b-Hydroxyestradiol 0.01 0.96 341.3072 C21H40O3 5-oxo-heneicosanoic acid 0.05 0.44 197.0513 C6H12O7 Gluconic acid 0.00 2.50 265.1882 C13H16N2O4 Alpha-N-Phenylacetyl-L-glutamine 0.01 2.81 235.1163 C12H14N2O3 5-Methoxytryptophan 0.04 3.37 105.0312 C4H8O3 3-Hydroxybutyric acid 0.03 5.52 423.2180 C12H23O14P Lactose 6-phosphate 0.04 6.76 591.3339 C33H42N4O6 D-Urobilinogen 0.01 2.61 261.1786 C11H20N2O5 L-gamma-glutamyl-L-leucine 0.02 2.94 281.1002 C13H16N2O5 L-beta-aspartyl-L-phenylalanine 0.04 5.50 254.1301 C9H11N5O4 Neopterin 0.04 5.91 247.1327 C9H14N2O6 5,6-Dihydrouridine 0.05 0.70 194.2085 C10H11NO3 2-Methylhippuric acid 0.03 2.23 148.1141 C5H9NO4 L-Glutamic acid 0.03 2.55 424.4137 C25H45NO4 Linoelaidyl carnitine 0.00 2.88 217.1739 C8H16N4O3 N-a-Acetyl-L-arginine 0.00 3.45 213.0921 C10H12O5 Vanillactic acid 0.00 4.98 203.2635 C8H18N4O2 Dimethyl-L-arginine 0.05 7