soluble mica and a mica variation as possible prognostic biomarkers for hbv-induced hepatocellular carcinoma可溶性云母,云母变异hbv-induced肝细胞癌的预后标志物.pdf

Soluble MICA and a MICA Variation as Possible Prognostic Biomarkers for HBV-Induced Hepatocellular Carcinoma 1,2 1 3 4 2 Vinod Kumar *, Paulisally Hau Yi Lo , Hiromi Sawai , Naoya Kato , Atsushi Takahashi , 1 1 1 3 5 Zhenzhong Deng , Yuji Urabe , Hamdi Mbarek , Katsushi Tokunaga , Yasuhito Tanaka , 6 6 4 7 7 Masaya Sugiyama , Masashi Mizokami , Ryosuke Muroyama , Ryosuke Tateishi , Masao Omata , 7 1 2 2 1 Kazuhiko Koike , Chizu Tanikawa , Naoyuki Kamatani , Michiaki Kubo , Yusuke Nakamura , Koichi Matsuda1 1 Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan, 2 Center for Genomic Medicine, The Institute of Physical and Chemical Research (RIKEN), Kanagawa, Japan, 3 Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 4 Unit of Disease Control Genome Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan, 5 Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan, 6 The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Chiba, Japan, 7 Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan Abstract MHC class I polypeptide-related chain A (MICA) molecule is induced in response to viral infection