ultraviolet radiation increases the toxicity of pyrene, 1-aminopyrene and 1-hydroxypyrene to human keratinocytes紫外线辐射增加芘毒性,1-aminopyrene 1-hydroxypyrene人类角质细胞.pdf

Int. J. Environ. Res. Public Health 2005, 2(1), 58-62 International Journal of Environmental Research and Public Health ISSN 1660-4601 © 2005 by MDPI Ultraviolet Radiation Increases the Toxicity of Pyrene, 1-Aminopyrene and 1-Hydroxypyrene to Human Keratinocytes Stephen I. N. Ekunwe1,2,3,*, Rochelle D. Hunter1,3, 4, and Huey-Min Hwang2,3 1 Microbial Molecular Genetics, Cancer and Phytonutriceuticals Research Laboratory 2NIH–Center for Environmental Health, College of Science, Engineering and Technology 3Department of Biology, Jackson State University, 1400 J. R. Lynch Street, P.O. Box 18540, Jackson, MS 39217, USA 4Pharmaceutical Products Development, Inc. (PPD), 980 Harvest Dr., Suite 130, Blue Bell, PA 19422, USA *Correspondence to: Stephen I. N. Ekunwe, Email: stephen.i.ekunwe@: Tel: (601) 979-3476; Fax: (601) 979-5853 Received: 15 November 2004 / Accepted: 06 February 2005 / Published: 30 April 2005 Abstract: Over the past several years, a great deal of interest has been focused on the harmful effects of ultraviolet (UV) radiation to human skin. UV light has been implicated in aging, sunburn and skin cancer. Few studies, however, have been done to determine the effects that UV light, in conjunction with other environmental contaminants, may have on human skin. Polycyclic Aromatic Hydrocarbons (PAHs) are a class of com