t cells and pathogenesis of hantavirus cardiopulmonary syndrome and hemorrhagic fever with renal syndromet细胞和汉坦病毒心肺综合症的发病机制与肾综合征出血热.pdf

Viruses 2011, 3, 1059-1073; doi:10.3390/v3071059 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Review T Cells and Pathogenesis of Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever with Renal Syndrome Masanori Terajima * and Francis A. Ennis Center for Infectious Disease and Vaccine Research, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA; E-Mail: Francis.Ennis@ * Author to whom correspondence should be addressed; E-Mail: Masanori.Terajima@; Tel.: +1-508-856-4182; Fax: +1-508-856-4890. Received: 31 March 2011; in revised form: 30 June 2011 / Accepted: 1 July 2011 / Published: 6 July 2011 Abstract: We previously hypothesized that increased capillary permeability observed in both hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS) may be caused by hantavirus-specific cytotoxic T cells attacking endothelial cells presenting viral antigens on their surface based on clinical observations and in vitro experiments. In HCPS, hantavirus-specific T cell responses positively correlated with disease severity. In HFRS, in one report, contrary to HCPS, T cell responses negatively correlated with disease severity, but in another report the number of regulatory T cells, which are thought to suppress T cell responses, negatively correlated with disease severity. In rat