原发性干燥综合征的发病机制（Pathogenesis of primary Sj grens syndrome）.doc

原发性干燥综合征的发病机制（Pathogenesis of primary Sj grens syndrome） Pathogenesis of primary Sj grens syndrome 2011-06-14 Tang Fulin Primary Sjogrens syndrome (pSS) is an autoimmune disease characterized by lymphocytic infiltration of the lacrimal gland and salivary glands, characterized by mouth and eye dryness. In addition to the symptoms of exocrine glands, the disease can also have symptoms of an external gland, such as arthritis, myalgia, rashes, and symptoms of visceral damage similar to systemic lupus erythematosus (SLE). Like other autoimmune diseases, the disease is destroyed by normal immune tolerance mechanisms and produces high titers of IgG antibodies to autoantigens. Because the target organ is easy to biopsy and the exocrine fluid is easy to collect, it has become a typical representative of HLA-DR related autoimmune diseases (type I diabetes mellitus, Hashimotos thyroiditis and multiple sclerosis). The criteria for the diagnosis of pSS is still the gold standard, unified therefore, caused the differences in clinical manifestations and pathogenesis analysis research, such as compliance with European diagnostic criteria only 15% patients met the diagnostic criteria of San Diego, apparently with different diagnostic criteria for clinical research, analysis and treatment of the observation results is certainly not the same. The pathogenesis of I degrees SS is mainly derived from animal models. For the diagnosis of strict pSS requirements, any animal model should have the following conditions: Anti SS-A and anti SS-B antibody; associated with certain HLA-DR and DQ alleles; gene expression of HLA-DR in glandular epithelial cells; some viruses, such as activation of EB virus; B lymphocyte proliferative disease increased, especially the expression the light chain of Vk III associated with rheumatoid factor B subtypes of B lymphocytes increased 1. 1 anti SS-A and anti SS-B antibodies Although antibodies against SS-A and SS-B are not unique antibodies in pSS, the positive