aqueous cytokine changes associated with posner-schlossman syndrome with and without human cytomegalovirus水与posner-schlossman综合症相关细胞因子的变化与人类巨细胞病毒,没有.pdf

Aqueous Cytokine Changes Associated with Posner- Schlossman Syndrome with and without Human Cytomegalovirus 1,2 1,3 3 1 1,3,6 Jing Li , Marcus Ang , Chui Ming Gemmy Cheung , Maya Vania , Anita Sook Yee Chan , 1,3 4 1,3,5 Samanthila Waduthantri , Henry Yang , Soon Phaik Chee * 1 Department of Ophthalmology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China, 2 Ocular Inflammation Group, Singapore Eye Research Institute, Singapore, Singapore, 3 Ocular Inflammation and Immunology Services, Singapore National Eye Centre, Singapore, Singapore, 4 Cancer Science Institute of Singapore, Singapore, Singapore, 5 Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, 6 Department of Pathology, Singapore General Hospital, Singapore, Singapore Abstract Aim: To study the differences in aqueous cytokines in Posner-Schlossman Syndrome (PSS) patients with and without human cytomegalovirus (CMV) DNA in the aqueous humor. Methods: This is a prospective study. Fifty-three uveitis patients with clinical signs of PSS were enrolled and aqueous humor samples were collected. Fourteen PSS patients were positive of CMV DNA in the aqueous by polymerase chain reaction (PCR) analysis. These eyes were negative of common ocular pathogens such as herpes simplex virus, varicella-zoster virus, rubella virus and toxoplasma. Twenty-five otherwise healthy cataract patients were enrolled as controls. Cytokine concentration was measured by a magnetic color-bead-based