the human cytomegalovirus ul11 protein interacts with the receptor tyrosine phosphatase cd45, resulting in functional paralysis of t cells人类巨细胞病毒ul11蛋白质与受体酪氨酸磷酸酶cd45交互,导致t细胞的功能瘫痪.pdf

The Human Cytomegalovirus UL11 Protein Interacts with the Receptor Tyrosine Phosphatase CD45, Resulting in Functional Paralysis of T Cells 1 ¨ 1 2 3 4 Ildar Gabaev , Lars Steinbruck , Claudia Pokoyski , Andreas Pich , Richard J. Stanton , Reinhard 2 1 5 1 1 Schwinzer , Thomas F. Schulz , Roland Jacobs , Martin Messerle *, Penelope C. Kay-Fedorov 1 Institute of Virology, Hannover Medical School, Hannover, Germany, 2 Department of General, Visceral and Transplantation Surgery, Hannover Medical School, Hannover, Germany, 3 Institute of Toxicology, Hannover Medical School, Hannover, Germany, 4 Section of Medical Microbiology, School of Medicine, Cardiff University, Cardiff, United Kingdom, 5 Department of Clinical Immunology and Rheumatology, Hannover Medical School, Hannover, Germany Abstract Human cytomegalovirus (CMV) exerts diverse and complex effects on the immune system, not all of which have been attributed to viral genes. Acute CMV infection results in transient restrictions in T cell proliferative ability, which can impair the control of the virus and increase the risk of secondary infections in patients with weakened or immature immune systems. In a search for new immunomodulatory proteins, we investigated the UL11 protein, a member of the CMV RL11 family. This protein family is defined by the RL11 domain, which has homology to immunoglobulin domains and adenoviral immunomodulatory proteins. We show that pUL11 is expressed on the cell surface and induces interc