association between markers of fatty liver disease and impaired glucose regulation in men and women from the general population the kora-f4-study之间的关联标记的脂肪肝和葡萄糖调节男性和女性从一般人群kora-f4-study.pdf
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Association between Markers of Fatty Liver Disease and
Impaired Glucose Regulation in Men and Women from
the General Population: The KORA-F4-Study
¨ 1 1,2 3 4 ¨ 1,5
Ina-Maria Ruckert *, Margit Heier , Wolfgang Rathmann , Sebastian E. Baumeister , Angela Doring ,
Christa Meisinger1,2
¨
1 Institute of Epidemiology II, Helmholtz Zentrum Munchen - German Research Center for Environmental Health (GmbH), Neuherberg, Germany, 2 MONICA/KORA
Myocardial Infarction Registry, Central Hospital of Augsburg, Augsburg, Germany, 3 Institute of Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for
¨ ¨
Diabetes Research at Heinrich Heine University Dusseldorf, Dusseldorf, Germany, 4 Institute for Community Medicine, University of Greifswald, Greifswald, Germany,
¨
5 Institute of Epidemiology I, Helmholtz Zentrum Munchen - German Research Center for Environmental Health (GmbH), Neuherberg, Germany
Abstract
Objective: To investigate whether the elevated liver enzymes gamma-glutamyltransferase (GGT), glutamate-pyruvate
transaminase (GPT), glutamate-oxalacetate transaminase (GOT) and alkaline phosphatase (AP) and non-alcoholic fatty liver
disease (NAFLD) respectively are independently associated with pre-diabetic states, namely impaired fasting glucose (IFG)
and impaired glucose tolerance (IGT) or known and newly diagnosed diabetes (NDD), in men and women from the general
German population.
Methods: The study was based on 3009 subjec
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