association between serum growth hormone levels and nonalcoholic fatty liver disease a cross-sectional study血清生长激素水平之间的联系和非酒精性脂肪肝病的横断面研究.pdf

Association between Serum Growth Hormone Levels and Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study 1,2. 2. 2 3 2 3 1 Lei Xu , Chengfu Xu , Chaohui Yu , Min Miao , Xuequn Zhang , Zhongwei Zhu , Xiaoyun Ding , Youming Li2* 1 Department of Gastroenterology, Ningbo No. 1 Hospital, Ningbo, China, 2 Department of Gastroenterology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China, 3 Department of Gastroenterology, Zhenhai Lianhua Hospital, Ningbo, China Abstract Growth hormone (GH) is an important regulator of metabolism and body composition. GH deficiency is associated with increased visceral body fat and other features of the metabolic syndrome. Here we performed a cross-sectional study to explore the association of GH levels with nonalcoholic fatty liver disease (NAFLD), which is considered to be the hepatic manifestation of the metabolic syndrome. A total of 1,667 subjects were diagnosed as NAFLD according the diagnostic criteria, and 5,479 subjects were defined as the controls. The subjects with NAFLD had significantly lower levels of serum GH than the controls. Those with low GH levels had a higher prevalence of NAFLD and the metabolic syndrome. A stepwise logistic regression analysis showed that GH levels were significantly associated with the risk factor for NAFLD (OR = 0.651, 95%CI = 0.574–0.738, P,0.001). Our results showed a significant association between lower serum GH levels and NAFLD. Citation: Xu L, Xu C, Yu C, Miao M, Zhang X, et al. (2012) Association between Serum Growth Hormone Levels and Nonalcoholic Fatty Liver Disease: A Cross- Sectional Study. PLoS ONE 7(8): e44136. doi:10.1371/journal.pone.0044136 Editor: Raul M. Luque, University of Cordoba, Spain