apoptosis of cd4+cd25high t cells in type 1 diabetes may be partially mediated by il-2 deprivation细胞凋亡的cd4 + t细胞cd25high 1型糖尿病可能被剥夺- 2介导.pdf

+ high Apoptosis of CD4 CD25 T Cells in Type 1 Diabetes May Be Partially Mediated by IL-2 Deprivation 1. 1. 1 1 1 1 Parthav Jailwala , Jill Waukau , Sanja Glisic , Srikanta Jana , Sarah Ehlenbach , Martin Hessner , 2 3 4 5 1 Ramin Alemzadeh , Shigemi Matsuyama , Purushottam Laud , Xujing Wang , Soumitra Ghosh * 1The Max McGee National Research Center for Juvenile Diabetes and The Human and Molecular Genetics Center, Department of Pediatrics at the Medical College of Wisconsin and the Children’s Research Institute of the Children’s Hospital of Wisconsin, Milwaukee, Wisconsin, United States of America, 2 Children’s Hospital of Wisconsin Diabetes Center, Pediatric Endocrinology and Metabolism, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, 3 Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, United States of America, 4 Division of Biostatistics, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, 5 Department of Physics the Comprehensive Diabetes Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America Abstract Background: Type 1 diabetes (T1D) is a T-cell mediated autoimmune disease targeting the insulin-producing pancreatic b cells. Naturally occurring FOXP3+ + high CD4 CD25 regulatory T cells (Tregs) play an important role in dominant tolerance, suppressing autoreactive CD4+