the colocalization potential of hiv-specific cd8+ and cd4+ t-cells is mediated by integrin β7 but not ccr6 and regulated by retinoic acid的colocalization潜力hiv-specific cd8 +及cd4 + t细胞是由整合素β7但不是ccr6和由视黄酸.pdf

The Colocalization Potential of HIV-Specific CD8+ and CD4+ T-Cells is Mediated by Integrin b7 but Not CCR6 and Regulated by Retinoic Acid 1,2 3 2 1,2,4 1 Vanessa Sue Wacleche , Nicolas Chomont , Annie Gosselin , Patricia Monteiro , Mathieu Goupil , 1,2 ´ 1,2 5 6 Hassen Kared , Cecile Tremblay , Nicole Bernard , Mohamed-Rachid Boulassel , Jean- Pierre Routy4,6,7, Petronela Ancuta1,2,4* ´ ´ ´ ´ 1 Department of Microbiology and Immunology, Universite de Montreal, Montreal, Quebec, Canada, 2 Centre Hospitalier de l’Universite de Montreal (CHUM)-Research ´ Center, Saint-Luc Hospital, Montreal, Quebec, Canada, 3 VGTI-Florida, Port St Lucie, Florida, United States of America, 4 INSERM Unit 743, Montreal, Quebec, Canada, 5 Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada, 6 Division of Hematology, McGill University Health Centre, Montreal, Quebec, Canada, 7 Immunodeficiency Service, Montreal Chest Institute, McGill University Health Centre, Montreal, Quebec, Canada Abstract CD4+ T-cells from gut-associated lymphoid tissues (GALT) are major targets for HIV-1 infection. Recruitment of excess effector CD8+ T-cells in the proximity of target cells is critical for the control of viral replication. He