《Effects of Scutellarin on Apoptosis Induced by Cobalt Chloride in PC12 Cells》.pdf

Chinese Journal of Physiology 50(6): 301-307, 2007 301 Effects of Scutellarin on Apoptosis Induced by Cobalt Chloride in PC12 Cells 1*, Ji-Ping Zeng2 *, Xin-Bing Wei1 3 1 Li-Xiang Wang , Fu-Wu Wang , Zhao-Ping Liu , and Xiu-Mei Zhang1 1Institute of Pharmacology 2Institute of Biochemistry and Molecular Biology and 3Institute of Histology and Embryology School of Medicine, Shandong University Jinan 250012, Shandong, P.R. China Abstract The present study investigated the protective effects of scutellarin on cobalt chloride (CoCl )- 2 µµ for 24 h resulted in induced apoptosis in PC12 cells. Incubation of PC12 cells with 500 µM CoCl µµ 2 significant apoptosis as evaluated by the crystal violet, electron microscopy and flow cytometry assays. The increase of caspase-3 activity, decrease of Bcl-XL expression, phosphorylation of p38 mitogen- activ