antibody to p. falciparum in pregnancy varies with intermittent preventive treatment regime and bed net use抗体恶性疟原虫在怀孕随间歇性预防治疗政权和蚊帐使用.pdf

Antibody to P. falciparum in Pregnancy Varies with Intermittent Preventive Treatment Regime and Bed Net Use 1 2 3 3 4 3,5 Elizabeth H. Aitken , Bernard Mbewe , Mari Luntamo , Teija Kulmala , James G. Beeson , Per Ashorn , Stephen J. Rogerson1* 1 Department of Medicine (RMH/WH), University of Melbourne, Parkville, Victoria, Australia, 2 Department of Community Health, College of Medicine, University of Malawi, Blantyre, Malawi, 3 Department of International Health, School of Medicine, University of Tampere, Tampere, Finland, 4 Burnet Institute, Melbourne, Victoria, Australia, 5 Department of Paediatrics, Tampere University Hospital, Tampere, Finland Abstract Background: Antibodies towards placental-binding P. falciparum are thought to protect against pregnancy malaria; however, environmental factors may affect antibody development. Methods and Findings: Using plasma from pregnant Malawian women, we measured IgG against placental-binding P. falciparum parasites by flow cytometry, and related results to intermittent preventive treatment (IPTp) regime, and bed net use. Bed net use was associated with decreased antibody levels at mid-pregnancy but not at 1 month post partum (1 mpp). At 1 mpp a more intensive IPTp regime was associated with decreased antibody levels in primigravidae, but not multigravidae. Conclusions/Significance: Results suggest bed nets and IPTp regime influence acquisition of pregnancy-specific P. falciparum immunity. Citation: Aitken EH, Mbewe B, Luntamo M, Kulmala T, Beeson JG, et al. (2012) Antibody to P. falciparum in Pregnancy Varies with Intermittent Preventive Trea