antibody to aquaporin 4 in the diagnosis of neuromyelitis optica水通道蛋白4抗体的诊断neuromyelitis视.pdf

PLoS MEDICINE Antibody to Aquaporin 4 in the Diagnosis of Neuromyelitis Optica 1,2[ 3,4,5[ 1,2[ 6 6 6 Friedemann Paul , Sven Jarius , Orhan Aktas , Martin Bluthner , Oliver Bauer , Heribert Appelhans , Diego Franciotta7 7 4,5 4,5 6 , Roberto Bergamaschi , Edward Littleton , Jacqueline Palace , Hans-Peter Seelig , Reinhard Hohlfeld3, Angela Vincent4,5, Frauke Zipp1,2* ´ 1 Cecilie-Vogt-Clinic for Molecular Neurology, Charite, University Medicine Berlin, Berlin, Germany, 2 Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany, 3 Institute of Clinical Neuroimmunology, University of Munich, Munich, Germany, 4 Department of Clinical Neurology, University of Oxford, Oxford, United Kingdom, 5 Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom, 6 Institute of Immunology and Molecular Genetics, Karlsruhe, Germany, 7 Istituto di Ricovero e Cura a Carattere Scientifico, Foundation Neurological Institute C. Mondino, University of Pavia, Pavia, Italy Funding: This work was supported A B S T R A C T by a grant of the Ministry of Education and Science to FZ ¨ (Bundesministerium fur Bildung und Forschung-NBL III), and partly by Background Collaborative Research Center grants to OA and FZ Neuromyelitis optica (NMO) is a demyelinating disease of t