antibody-based detection tests for the diagnosis of helicobacter pylori infection in children a meta-analysis基于抗体的检测测试儿童幽门螺杆菌感染的诊断分析.pdf

Antibody-Based Detection Tests for the Diagnosis of Helicobacter pylori Infection in Children: A Meta-Analysis 1 2 ´ ´ 1 1 3 Yelda A. Leal *, Laura L. Flores , Laura B. Garcıa-Cortes , Roberto Cedillo-Rivera , Javier Torres ´ ´ ´ ´ ´ ´ ´ ´ 1 Unidad de Investigacion Medica Yucatan (UIMY), Unidad Medica de Alta Especialidad de Merida, Instituto Mexicano del Seguro Social, Merida, Yucatan, Mexico, 2 Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital and the University of California San Francisco, San Francisco, California, United States of ´ ´ ´ ´ America, 3 Unidad de Investigacion Medica en Enfermedades Infecciosas y Parasitarias (UIMEIP)–Hospital de Pediatrıa Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, D.F., Mexico Abstract Background: Numerous serologic tests are available for the diagnosis of H. pylori infection in children. Common designs of antibody-based detection tests are ELISA and Western Blot (WB). For developing countries with limited laboratory resources and access, ELISA would be the preferred method because of its simplicity, lower cost and speed. Although in adults ELISA has proven to be highly accurate in diagnosing H. pylori infection; in children, it has shown variable accuracy. Methods/Findings: We conducted a systematic review and meta-analysis to assess the accuracy of antibody-based detection te