built shallow to maintain homeostasis and persistent infection insight into the transcriptional regulatory network of the gastric human pathogen helicobacter pylori建立浅维持体内平衡和持续感染洞察的转录调控网络胃幽门螺杆菌人类病原体.pdf

Review Built Shallow to Maintain Homeostasis and Persistent Infection: Insight into the Transcriptional Regulatory Network of the Gastric Human Pathogen Helicobacter pylori 1 2 1 Alberto Danielli *, Gabriele Amore *, Vincenzo Scarlato 1 Department of Biology, University of Bologna, Bologna, Italy, 2 Animal Physiology and Evolution Laboratory, Stazione Zoologica Anton Dohrn, Napoli, Italy TRNs commonly exhibit multilayered hierarchical structures, Abstract: Transcriptional regulatory networks (TRNs) composed of regulatory modules (origons) that include the transduce environmental signals into coordinated output concerted activity of transcription factors (TFs) regulating related expression of the genome. Accordingly, they are central physiological functions [11]. Origons therefore embody regulatory for the adaptation of bacteria to their living environments sub-networks that originate at a distinct class of sensor TFs, and in host–pathogen interactions. Few attempts have rooting a signal input node [12]. Each origon comprises a master been made to describe a TRN for a human pathogen, regulator, sensing a specific signal, followed by intermediate TFs because even in model organisms, such as Escherichia coli, the analysis is hindered by the large number of and regulatory interactions that ultimately feed into output gene transcription factors involved. In light of the paucity of target