comparative analyses of pandemic h1n1 and seasonal h1n1, h3n2, and influenza b infections depict distinct clinical pictures in ferrets比较分析了h1n1大流行性流感和季节性h1n1流感病毒h3n2,描绘不同的临床图片和乙型流感感染雪貂.pdf

Comparative Analyses of Pandemic H1N1 and Seasonal H1N1, H3N2, and Influenza B Infections Depict Distinct Clinical Pictures in Ferrets 1,2 1 1,2 1 1 Stephen S. H. Huang , David Banner , Yuan Fang , Derek C. K. Ng , Thirumagal Kanagasabai , David J. Kelvin1,2,3,4,5*, Alyson A. Kelvin3 1 Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada, 2 Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada, 3 Immune Diagnostics and Research, Toronto, Ontario, Canada, 4 International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China, 5 Dipartimento di Scienze Biomediche, Universita’ degli Studi di Sassari, Sassari, Sardinia, Italia Abstract Influenza A and B infections are a worldwide health concern to both humans and animals. High genetic evolution rates of the influenza virus allow the constant emergence of new strains and cause illness variation. Since human influenza infections are often complicated by secondary factors such as age and underlying medical conditions, strain or subtype specific clinical features are difficult to assess. Here we infected ferrets with 13 currently circulating influenza strains (including strains of pandemic 2009 H1N1 [H1N1pdm] and seasonal A/H1N1, A/H3N2, and B viruses). The clinical parameters were measured daily for 14 days in stable environmental conditions to compare clinical characteristics. We found that H1N1pdm strains had a more severe physiological impact than all season strains where pandemic A/California/07/2009 was the most clinically pathogenic pandemic strain. The most