the association of apoe genotype with cognitive function in persons aged 35 years or older协会的apoe基因型与认知功能在35岁以上的人.pdf

The Association of APOE Genotype with Cognitive Function in Persons Aged 35 Years or Older 1,2 3 4 3 4 Gerbrand J. Izaks *, Ron T. Gansevoort , Aafke M. van der Knaap , Gerjan Navis , Robin P. F. Dullaart , Joris P. J. Slaets1,2 1 University Center for Geriatric Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, 2 Alzheimer Center Groningen, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, 3 Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, 4 Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Abstract APOE genotype is associated with the risk of Alzheimer’s disease. In the present study, we investigated whether APOE genotype was associated with cognitive function in predominantly middle-aged persons. In a population-based cohort of 4,135 persons aged 35 to 82 years (mean age (SD), 55 (12) years), cognitive function was measured with the Ruff Figural Fluency Test (RFFT; worst score, 0 points; best score, 175 points). APOE genotype (rs429358 and rs7412) was determined by polymerase chain reaction. The mean RFFT score (SD) of the total cohort was 69 (26) points. Unadjusted, the mean RFFT score in homozygous APOE e4 carriers was 4.66 points lower than in noncarriers (95% confidence interval, -9.84 to 0.51; p = 0.08). After adjustment for age and other risk factors, the mean RFFT score in homozygous APOE e4 carriers was 5.24 points lower than in noncarriers (95% confidence interval, -9.41 to -1.07; p = 0.01). The difference in RFFT score was not dependent on age. There was no differe