cognitive function in childhood and lifetime cognitive change in relation to mental wellbeing in four cohorts of older people认知功能在童年和终身的认知变化与四群老年人精神健康.pdf

Cognitive Function in Childhood and Lifetime Cognitive Change in Relation to Mental Wellbeing in Four Cohorts of Older People 1,2 3 4 5 3 3 Catharine R. Gale *, Rachel Cooper , Leone Craig , Jane Elliott , Diana Kuh , Marcus Richards , 2,6 4 2 John M. Starr , Lawrence J. Whalley , Ian J. Deary on behalf of the HALCyon Study Team 1 MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom, 2 Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom, 3 MRC Unit for Lifelong Health and Ageing, University College London, London, United Kingdom, 4 Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom, 5 Centre for Longitudinal Studies, Institute of Education, University of London, London, United Kingdom, 6 Geriatric Medicine Unit, University of Edinburgh, Royal Victoria Hospital, Edinburgh, United Kingdom Abstract Background: Poorer cognitive ability in youth is a risk factor for later mental health problems but it is largely unknown whether cognitive ability, in youth or in later life, is predictive of mental wellbeing. The purpose of this study was to investigate whether cognitive ability at age 11 years, cognitive ability in later life, or lifetime cognitive change are associated with mental wellbeing in older people. Methods: We used data on 8191 men and women aged 50 to 87 years from four cohorts in the HALCyon collaborative research programme into healthy ageing: the Aberdeen Birth Cohort 1936, the Lothian Birth Cohort 1921, the National Child Development Survey, and the MRC